NFL Quarterback Club (USA, Europe) is an American Football game for the Game Boy. As a likely earlier installment in the series, it offered a portable way for fans to experience the sport.  More information is required about the exact release date and original publishers.  Gameplay would have focused on managing the quarterback's actions, with controls adapted to the Game Boy hardware. This game contributed to the growth of sports titles on the platform. 

NFL Quarterback Club (USA, Europe)

NFL Football (USA)